Fumefx Production Settings

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I was given a Smoke file from someone else for a production.
I'm not very experienced with Fume and need to get results quickly.
After trying to simulate the file, the render time was around 15 hours.
I know from other shots in the production that this is much too long.
What are settings that I can adjust that will produce quality simulations but not eat up so much sim time?

Any help is greatly appreciated!